Pfizer Handbook of Microbial Metabolites 242 



497 Spinulosin, CgHgOg, purple-black plates, m.p. 203°. 



CH3 ? OH 



HO I OCH3 



First isolated from three strains of Penicillium spinu- 

 losiim Thorn grown on a modified Czapek-Dox-glucose 

 medium. Later isolated from two out of seven strains of 

 Aspergillus fumigatus examined. Spinulosin as well as 

 an orange pigment, m.p. 184-185°, with antibiotic prop- 

 erties resembling those of fumigatin, also has been iso- 

 lated from an unidentified Penicillium (perhaps Penicil- 

 lium spinulosumy Penicillium cinerascens Biourge is 

 another producer. 



J. H. Birkinshaw and H. Raistrick, Trans. Roy. Soc. (Lon- 

 don) B220 245 (1931). 



Winston K. Anslow and Harold Raistrick, Biochem. J. 32 

 687, 2288 (1938). (Isolation) 



A. Bracken and H. Raistrick, ibid. 41 569 (1947). 



Keichiro Hoshishima, Tohuku J. Exptl. Med. 52 273 (1950). 



Winston K. Anslow and Harold Raistrick, Biochem. J. 32 

 803 (1938). (Synthesis) 



498 Aurantiogliocladin, CioHjoOj, orange plates, m.p. 62.5°. 



CH3 II OCH3 



CH3 I OCH3 



The corresponding quinhydrone, a dark red compound 

 called rubrogliocladin, occurs together with aurantioglio- 

 cladin. 



A Gliocladium specimen, probably G. roseum Bainier 

 produces these substances as well as : 



