Pfizer Handbook of Microbial Metabolites 



270 



586 Rugulosin (Radicalisin), C30H00O10, yellow prisms, m.p. 293' 

 (dec), [a]546i'' +605° (dioxane). 



Penicillium rugulosum Thorn, P. tardum Thorn, P. 

 wortmanni Klocker, Endothia parasitica (Murr. ) Ander- 

 son and Anderson, E. fiiiens Shear and Stevens. 



About 20% of the dry weight of P. rugulosum myce- 

 lium is rugulosin. 



J. Breen, J. C. Dacre, H. Raistrick and G. S. Smith, 

 Biochem. J. 60 618 (1955). 



Shoji Shibata, Osamu Tanaka, Goro Chihara and Horoshl 

 Mitsuhashi, Pharm. Bull. (Tokyo) 1 302 (1953). 



Shoji Shibata, Takao Murakami, Osamu Tanaka, Goro Chi- 

 hara, Isao Kitagawa, Masashi Sumimoto and Chikara Kaneko, 

 ibid. 3 160 (1955). (Structure) 



Shoji Shibata, Takao Murakami, Osamu Tanaka, Goro Chi- 

 hara and Masashi Sumimoto, ibid. 3 274 (1955). 



Yazuru Yamamoto, Akira Hamaguchi, Isao Yamamoto and 

 Sumie Imai, J. Pharm. Soc. Japan 76 1428 (1956). 



Shoji-Shibata and Isao Kitagawa, Pharm. Bull. (Tokyo) 4 

 309 (1956). (Structure) 



587 Rubroskyrin, C30H22O12, dark red plates, m.p. 289° (dec). 



O O OH 



