277 



Tetracycline, Analogues and Related Substances 



Hans Brockmann and Burchard Franck, Chem Ber 88 1792 

 (1955). (Isolation) 

 Other references: 

 Hans Brockmann and Klaus Bauer, Naturivissenschaften 37 



Hans Brockmann, Klaus Bauer and Use Borchers Chem 

 Ber. 84 700 (1951). 



Hans Brockmann and Enno Spohler, Naturivissenschaften 

 42 154 (1955). (Characterization of rhodosamine) 



Hans Brockmann, German Patent 913,813 (1954). 



602 7-Chloro-6-demethyltetracycline, C,iH,iOsNoCl (isolated as the 

 sesquihydrate), yellow crystals, m.p. 174-178° (dec ) 

 [<x]^-' -258° (0.5% in 0.1 N sulfuric acid). ' ' 



CONH2 



Streptomyces aureofaciens Duggar (mutant) 



J. R. D. McCormick, NeweU O. Sjolander, Ursula Hirsh 



Ekner R. Jensen and Albert P. Doerschuk, /. Am. Chem Soc 



79 4561 (1957). 



603 6-Demethyltetracycline, CaiHssOgNoCl (isolated as the hydro- 

 chloride hemihydrate), yellow crystals, m.p. 203-209° 

 (dec), [aJD -259° (c 0.5 in 0.1 N sulfuric acid). 



CONH2 



Streptomyces aureofaciens Duggar (mutant) 



J. R. D. McCormick, Newell O. Sjolander, Ursula Hirsh, 



Elmer R. Jensen and Albert P. Doerschuk, /. Am. Chem. Soc 



79 4561 (1957). 



