Pfizer Handbook of Microbial Metabolites 280 



C. W. Waller, B. L. Hutchings, R. W. Broschard, A. A. Gold- 

 man, W. J. Stein, C. F. Wolf and J. H. Williams, ibid. 74 4981 

 (1952). 



609 Bromotetracycline, CooHogOgN.Br, m.p. 170-172°, [ale'" -196° 

 (in 0.1 N hydrochloric acid). 



000 

 H H 



CONH2 



Streptomyces aureofaciens 



P. Sensi, G. A. DeFerrari, G. G. Gallo and G. Holland, II 

 Farmaco Ed. sci. (Pavia) 10 337 (1955). 



610 Oxytetracycline ( Terramycin ) , C00H04O9N2, light-yellow crys- 

 tals, m.p. (anhydride) '--'185° (dec), [ajo'^ (dihydrate) 

 -196.6° (c 1.0 in 0.1 N hydrochloric acid). 



CH3 CH3 



CH3 OH OH N 



OH 



CONH2 

 OH O OH ^ 



Streptomyces rimosus 



A. C. Finlay, G. L. Hobby, S. Y. P'An, P. P. Regna, J. B. 

 Routien,-D. B. Seeley, G. M. ShuU, B. A. Sobin, I. A. Solomons, 

 J. W. Vinson and J. H. Kane, Science 111 85 (1950). (Iso- 

 lation) 



Ben A. Sobin, Alexander C. Finlay and Jasper H. Kane, 

 U. S. Patent 2,516,080 (1950). 



Peter P. Regna, I. A. Solomons, Kotaro Murai, Albert E. 

 Timreck, Karl J. Brunings and W. A. Lazier, J. Am. Chem. 

 Soc. 73 4211 (1951). 



C. R. Stephens, L. H. Conover, F. A. Hochstein, P. P. Regna, 

 F. J. Pilgrim, K. J. Brunings and R. B. Woodward, ibid. 74 

 4976 (1952). 



F. A. Hochstein, C. R. Stephens, L. H. Conover, P. P. Regna, 

 R. Pasternack, P. N. Gordon, F. J. Pilgrim, K. J. Brunings and 

 R. B. Woodward, ibid. 75 5455 (1953). (Structure) 



611 Antibiotic X-340, CosHooOe, yellow needles, m.p. 330° (dec). 

 An antibiotic isolated from the mycelium of an uniden- 



