Pfizer Handbook of Microbial Metabolites 



282 



Tetracycline was first prepared by catalytic dechlorina- 

 tion of chlortetracycline but was later isolated as a pri- 

 mary fermentation product. 



P. Paul Miuieri, Melvin C. Firman, A. G. Mistretta, Anthony 

 Abbey, Clark E. Bricker, Neil E. Rigler and Herman Sokol, 

 "Antibiotics Annual 1953-1954," Medical Encyclopedia, Inc., 

 New York, p. 81. (Isolation) 



614 Quinocyclines (PA-121) 



A complex of tetracyclic amphoteric antibiotic yellow 

 pigments, which in some respects resemble nitrogen-con- 

 taining hydroxy anthraquinones. 



Six active components have been separated and analy- 

 ses and color reactions were determined. 



Two components have an aglycone with the probable 

 empirical formula Co-H^oOc.N^. 



Streptomyces sp. 



W. D. Celmer, K. Murai, K. V. Rao, F. W. Tanner, Jr. and 

 W. S. Marsh, "Antibiotics Annual 1957-1958," Medical En- 

 cyclopedia, Inc., New York, p. 484. (Isolation) 



Charles R. Stephens, unpublished. (Empirical formula) 



615 7;-Pyrromycin, C30H35O11N (Hydrochloride), red crystals, m.p. 



162° (dec), [a]c,r" +132 ±27° (c 0.4 in methanol). 



CH3I 



>Rhodosamine 



OH O 



CH2 

 COOCH3 



A streptomycete 



The relationship to e-pyrromycinone and to the cineru- 

 bins should be noted. 



Hans Brockmann and Werner Lenk, Chem. Ber. 92 1904 

 (1959). (Structure) 



Hans Brockmann and Hans Brockmann, Jr., Naturwis- 

 senschaften 47 135 (1960). 



