Pfizer Handbook of Microbial Metabolites 



334 



It appears that an adenylic acid-pantoate complex is the inter- 

 mediate which couples with the enzyme. 



NHj 



sXn 



o o 



T T I 



CH,— O— P— O— P— O— CH2— C 



OH 



OH 



CH3 OH O 



I I II 



CH— C— NH— CH2— CH,— COOH 



CH3 



Pantothenylcysteine is a precursor of pantetheine in Lactobacil- 

 lus helveticus.^ 



The red actinomycins were the first antibiotics isolated crys- 

 talline from actinomycetes/' In the ensuing 20 years about a 

 dozen named species of streptomycetes have been found to pro- 

 duce actinomycins, and probably many other isolates have gone 

 unreported. 



TABLE I 

 Chronological List of Microorganisms Reported to Produce Actinomycins* 



5 Gene M. Brown, /. Biol. Chem. 226 651 (1957). 

 « S. A. Waksman and H. B. Woodruff, Proc. Soc. Exp. Biol. 45 609 

 (1940). 



