347 Polypeptides and Related Compounds 



Jean Paul Aubert, Jacqueline Millet, Elisabeth Pineau and 

 Gerard Milhaud, Compt. rend. 249 1956 (1959). 



715 Lycomarasmine, CjiHi-.O-N.., white powder, m.p. 227-229 (dec). 

 Tentative structure : 



H,N-CO-CH, CH3 



HOOC— CH— NH— CO— CH,— NH— C— OH 



COOH 



Fusariinn lycopersici Sacc. 



This is the toxin of fusarium wilt. A second compound, 

 C9H1.O-N0, white powder, m.p. 273-276° (dec), has been 

 isolated from the mother Hquors. It is produced in up to 

 three times the yield of lycomarasmine, but is biologically 

 inactive. It is also produced (with evolution of ammonia) 

 by boiling lycomarasmine with water. 



The yield of lycomarasmine in the initial isolation was 

 80-110 mg. per liter. 



There is still some dissatisfaction with this structure. 



PI. A. Plattner and N. Clauson-Kaas, Helv. Chim. Acta 28 

 188 (1945). (Isolation) 



D. W. WooUey, ;. Biol. Chem. 176 1291 (1948). (Struc- 

 ture) 



M. Brenner, R. Tamm and P. Quitt, Helv. Chim. Acta 41 

 763 (1958). (Criticism of structure) 



716 d-Pantothenic Acid, C^Hi-OsN, viscous oil, [aji,-' +37.5° (in wa- 

 ter). 



CH3 O 



HOCH2— C— CH— C— NH— CH— CHCOOH 



I 1 

 CH3OH 



Penicillin liquors yield 600-800 /xg. per gram of dry 

 cell weight. 



Yeasts contain 150-300 fxg. per gram of dry cell weight. 



D. W. WooUey, /. Am. Chem. Soc. 62 2251 (1940). (Syn- 

 thesis ) 



Leland A. Underkofier and Richard J. Hickey, "Industrial 

 Fermentations," Chemical Publishing Co., Inc., New York, 

 1954 Vol. II, J. M. Van Lanen, Production of vitamins other 

 than riboflavin, chap. 6, pp. 191-216. 



