Pfizer Handbook of Microbial Metabolites 348 



717 Toxin of tobacco wild-fire disease, C10H16O6N2. 



Probable structure: 



NH2 OH 



I I 



HOOC— CH— CH.— CHo— CH— CH— C=0 



I I 

 NH O 



1 I 

 0=C CH— CH3 



Pseudomonas tabaci 



The toxin can by hydrolyzed to lactic acid and the 

 amino acid, tabtoxinin, C7H14O5N2, (a,e-diamino-/3-hy- 

 droxypimelic acid ) : 



HOOC— CH— CH2— CHo— CH— CH— COOH 



I II 



NH2 OH NH2 



D. W. Woolley, G. Schaffner and Armin C. Braun, J. Biol. 

 Chem. 198 807 (1952). (Isolation) 



Idem., ibid. 215 485 (1955). (Structure) 



718 Glutathione (Glutamylcysteinylglycine) CiyHi^OoNgS, colorless 



crystals, m.p. 190-192° (dec). Unstable. [a]Hg.'' ' -9.4° 

 in water, —85° in 10% hydrochloric acid. 



O O 



II ■ II 



HOOC— CH— CH2— CH2— C— NH— CH— C— NH— CH2— COOH 



I I 



NH2 CH2SH 



Yeasts 



F. G. Hopkins, Biochem. J. 15 286 (1921). (Isolation) 

 Charles Robert Harington and Thomas Hobson Mead, ibid. 

 29 1602 '(1935). (Synthesis) 



719 N-Succinyl-L-diaminopimelic Acid, CnHigOjN^. 



NH2 



HOOC— CH—CH,CH2CH2—CH— COOH 



NH— C— CH2CH2COOH 



II 

 O 



Charles Gilvarg, Biochim. et Biophys. Acta 24 216 (1957). 



Lactobacillus bulgaricus Factor (Pantetheine and Pantethine), 

 C11H00O4N0S and C22H4.O8N4S.. 



