35 1 Polypeptides and Related Compounds 



j3-Hydroxyleucine 



CH3 



\ 



CH— CH— CH— COOH 



/ I ! 



CH3 OH NH> 



as well as L-leucine, ^-alanine and y-methylproline. The 

 ytJ-hydroxyleucine, which had not been reported previously 

 as a natural product, has either the d- or L-t/zreo but not 

 the erythro configuration. 



A Paecilomyces strain 



G. W. Kenner and R. C. Sheppard, Nature 181 48 (1958). 



727 Viomycin (Vinactin A, Vinactane, Celiomycin, Viocin), 



CiT-isHsi-sjOsNg, Sulfate: m.p. (anhydrous) 252° (dec.) 

 (hydrated) 280° (dec), [a],,--' -32° (c 1 in water). Rota- 

 tion varies with pH. 



A strongly basic polypeptide. The following compo- 

 nents have been identified: a,/^-diaminopropionic acid, /?- 

 lysine, L-serine and a guanidino compound. Salts are 

 neutral. 



Streptomyces fioridae, S. puniceus, S. vinaceus 



A. C. Finlay, G. L. Hobby, F. Hochstein, T. M. Lees, T. F. 

 Lenert, J. A. Means, S. Y. P'An, P. P. Regna, J. B. Routlen, 

 B. A. Sobin, K. B. Tate and J. H. Kane, Am. Rev. Tuberc. 63 1 

 (1951). 



Quentin R. Bartz, John Ehrllch, James D. Mold, Mildred A. 

 Penner and Robert M. Smith, ibid. 63 4 (1951). 



Theodore H. Haskell, Salvatore A. Fusari, Roger P. Frohardt 

 and Quentin R. Bartz, J. Am. Chem. Soc. 74 599 (1952). 



R. L. Mayer, P. C. Eisman and E. A. Konopka, Experientia 

 10 335 (1954). 



728 Phthiomycin, white powder. 



A basic polypeptide resembling viomycin. 

 Streptomyces luteochromogenes n. sp. 

 Kenji Maeda, Yoshiro Okami, Ryozo Utahara, Hiroko Kosaka 

 and Hamao Umezawa, /. Antibiotics (Japan) 6A 183 (1953). 

 Yasushi Miyamoto and Kenji Maeda, ibid. 7A 17 (1954). 



729 Streptolin A, Ci^H^iOsN,, or C.4H4,,OiiN-, m.p. 206° (dec), sul- 



fate UW-' -20°. 



Streptolins A and B are similar. They resemble strepto- 

 thricin, viomycin, geomycin and roseothricin in their acid 

 hydrolysates, which contain L-/;j-lysine, a-D-gulosamine, 

 streptolidine, ammonia and carbon dioxide. 



