Pfizer Handbook of Microbial Metabolites 



358 



PA 114 Antibiotics. 



743 PA 114A,* Cor.H^iOeNa or C35H42O9N4 (proposed), colorless nee- 



dles, m.p. 200° (dec), [a],,'' -207° (c 0.5 in methanol). 

 A neutral substance, green FeCla test. Negative ninhy- 

 drin, carbohydrate tests. 



744 PA 114B,t C^oHeaO^oN;, (proposed), colorless crystals, m.p. 265° 



(dec), [alD^-" -59.7° (c 0.5 in methanol). 



A weak acid, red FeCl^ test. Negative ninhydrin, carbo- 

 hydrate tests, 2,4-DNPH. 



Streptomyces olivaceus 



Walter D. Celmer and Ben A. Sobin, "Antibiotics Annual 

 1955-1956," Medical Encyclopedia, Inc., New York, p. 437. 



745 PA 114B-3, colorless needles, m.p. 207°, [a]i,-'' -37.2° (in 



methanol). 



A polypeptide antibiotic similar to PA-114B. Analysis: 

 C 62.77, H6.52, N 12.61. 



A Streptomyces olivaceus strain 



D. C. Hobbs and W. D. Celmer, Federation Proc. 18 246 

 (1959). 



746 Streptogramin, approximate formula CocH^^O-N,, m.p. 155°, 



[all, -134°. 



Neutral compound. 



Streptomyces gr amino faciens 



Jesse Charney, W. P. Fisher, Charles Curran, Roy A. 

 Machlowitz and Alfred A. Tytell, "Antibiotics Annual 1953- 

 1954," Medical Encyclopedia, Inc., New York, p. 171. 



Lateritiin Group 



Several colorless compounds similar to the enniatins 

 were isolated from fusaria species in England. One of 

 these, lateritiin I, has been shown identical vsdth enniatin 

 A. The others are : 



747 



748 

 749 

 750 



A). 



All these compounds yield D( — )-a-hydroxyiso valeric 

 May be identical with staphylomycin M^, E-129A (ostreogrycin 



t See addendum for structure. 



