36i 



Polypeptides and Related Compounds 



H. Vanderhaege, Abstr. Biochem. Symposium, XVIIth 

 Internat. Congress Pure and Appl. Chem., Munich 1959. 



H. Vanderhaege and G. Parmentier, Bull. Soc. Chim. beiges 

 68 716 (1959). 



756 Phalloidin, C35H46O10NSS + SHoO. 

 CHs 



HOCH2 



:=CH— CH— NH 



CHOH 



Amanita phalloides 



From 100 g. of fresh fungus were obtained 10 mg. of 

 phalloidin, 8 mg. of x-amanitin, 5 mg. of /?-amanitin and 

 about 0.5 mg. of y-amanitin. The amanitins have not 

 been characterized thoroughly, but seem to be related to 

 phalloidin. 



Theodor Wieland, Angew. Chem. 69 44 (1957). 



Theodor Wieland and Werner Schon, Ann. 593 157 (1955). 



Theodor Wieland and Christoph Dudensing, ibid. 600 156 

 (1956). 



757 Phalloin, CssH^gOgNsS, colorless needles, m.p. 250-280° (dec). 

 Probable structure: 



CHo CHOH 



CH3 



CH3 



C=CH— CH- 



NH- 



CO- 



CH2 



-CH— NH— CO— CH 



CH2 



^N" 



CH3 



c=o 



I 



NH 



I 

 -CH 



I 



c=o 



NH 



X 



-CH 



CO 



CH.. 



CO 



CH— CH3 



CH 



:O^NH 



-NH 



HCOH 



I 

 CHs 



