Pfizer Handbook of Microbial Metabolites 362 



Amanita phalloides 



Theodor Wieland and Karl Mannes, Angew. Chem. 69 389 

 (1957). 



Idem., Ann. 617 152 (1958). 



758 Valinomycin, C;jf;H(;oOi:,N4, colorless platelets, m.p. 190°, [air'" 

 +31° (c 1.6 in benzene). 



CH3 



\ II CH-CHa 



^0\-—^ ^NH.^ / 



O /O L-Lactic Acid CH Q 



\ > L-Valine K 



^"\ / \ 



/ CH O CHs 



CH3 7 D-Valine \ / 



W\\ D-a-Hydroxyisovaleric CM \ 



o=c c=o 



^^. \ D-a-Hydroxyisovaleric / 



\ CH Acid NH 



/ \ D-Valine / CH3 



CH3 q /CH / 



C L-Vaiine L-Lactic ,C 



/ \ Acid y V 



CH 



CH3 



NH^ n -CH 



c- 



CH \ \ 



CH3 CHa 



O 



CH 



Streptomyces fulvissimus 



The yield was about 100 mg. per liter. Acid hydrolysis 

 gives 2 moles of L( + )-valine, 2 moles of d( — )-vahne, 2 

 moles of l( — )-lactic acid and 2 moles of d( — )-a-hydroxy- 

 isovaleric acid. (Cf. the enniatin and lateritiin groups, 

 and amidomycin.) 



H. Brockmann and G. Schmidt-Kastner, Chem. Ber. 88 57 

 (1955). 



Hans Brockmann and Hermann Geeren, Ann. 603 213 

 (1957). 



759 Viscosin, C;{,.H,j,;0]„N,;, amorphous white powder, m.p. 269° 

 (dec), [a],r" -162°. 



