Pfizer Handbook of Microbial Metabolites 364 



J. M. Waisvisz, M. G. van der Hoeven, J. van Peppen and 

 W. C. M. Zwennis, J. Am. Chem. Soc. 79 4520 (1957). (Iso- 

 lation ) 



J. M. Waisvisz, M. G. van der Hoeven, J. F. Holscher and 

 B. te Nijenhuis, ibid. 79 4522 (1957). 



J. M. Waisvisz, M. G. van der Hoeven and B. te Nijenhuis, 

 ibid. 79 4524 (1957). (Structure) 



Micrococcins. 



761 Micrococcin, white needles, m.p. 222-228° (dec.), [aln^^ 116° 



±1° (c 5.0 in 90% ethanol), molecular weight >2000. 



A Micrococcus sp. 



T. L. Su, Brit. J. Exptl. Path. 29 473 (1948). 



N. G. Heatley and Hazel M. Doery, Biochem. J. 50 247 

 (1951). 



762 Micrococcin-P, white crystals, yellowing in light, m.p. 252° (dec. 



from 232°), [ale"' +63.7° (c 1.19 in 90% ethanol), mo- 

 lecular weight '-'2200. 



Two fragments have been identified as : 



HOOC HOOC 



C— CH2CH3 CH— CH 



CH3 



O NH2 CH3 



2-Propionylthiazole-4- 2-(l -Amino-2-methylpropyl) 



carboxylic Acid thiazole-4-carboxylic Acid 



Acid-catalyzed esterification gave a dimethyl ester, 

 C24Ho365Nr,S4 and a base CifiHictO^N^S-^. Also threonine, 

 ammonia and propionic acid were isolated. 



This antibiotic seems to be similar to or identical with 

 the earlier one, but is distinguished by the letter P until 

 identity is proved. 



Bacillus pumilis 



A. T. Fuller, Nature 175 722 (1955). (Isolation) 



E. P. Abraham, N. G. Headey, P. Brookes, A. T. Fuller and 

 James Walker, ibid. 178 44 (1956). 



P. Brookes, A. T. Fuller and James Walker, J. Chem. Soc, 

 689 (1957). 



