Pfizer Handbook of Microbial Metabolites 366 



Donald M. Reynolds, Albert Schatz and Selman A. Waks- 

 man, Proc. Soc. Exp. Biol. 64 50 (1947). (Isolation) 



Donald M. Reynolds and Selman A. Waksman, /. Bad. 

 55 739 (1948). 



Frederick A. Kuehl, Jr., Mary Neale Bishop, Louis Chaiet 

 and Karl Folkers, J. Am. Chem. Soc. 73 1770 (1951). 



766 Albomycin (Sulfate), red amorphous powder, molecular weight 



>1300. 



Partial Constitution: 



Albomycin is a basic, cyclic polypeptide containing iron 

 (^4% by weight). Iron can be removed with acetone 

 (color loss) and restored with FeCl^. Hydrolysis yields: 

 ornithine, serine, glutamic acid, alanine, glycine, proline 

 and one unidentified amino acid. 



Streptomyces siibtropicus n. sp. 



Albomycin may be identical with grisein, produced by 

 Streptomyces griseus. 



M. G. Brazhnikova, N. N. Lomakina and L. I. Murayeva, 

 Dokladij Akad. Nauk S.S.S.R. 99 827 (1954). 



G. F. Gause, Brit. Med. J. 2 1177 (1955). 



Yu. O. Sazykin, Mikrobiologiya 24 75 (1955). 



767 Amidomycin, C4i|H,.sOi2N4, colorless needles, m.p. 192°, [a]i)^*' 



+ 19.2° (c 1.2 in ethanol). 



CHj CH3 

 \ / CH3 CH3 



CH O \ / 



\ It CH 



^CH C — -Q / 



CH3 O. /NH CH o 



CH 



D-Hiv 



/ ^CH D-Hiv NH CH3 



^ i / 



o 



o=c 



CH3 \ 



rw— CH D-Val 



/ \ 



CH3 NH 



\ 



CH 



/ \ 



CH3 CH:, 



Streptomyces species (PRL 1642) 



Amidomycin contains 4 moles each of d( — ) valine and 

 d( — ) a-hydroxyisovaleric acid. (Cf. Valinomycin, lateri- 

 tiins, enniatins.) 



L. C. Vining and W. A. Taber, Can. J. Chem. 35 1109 

 (1957). 



