3^7 Polypeptides and Related Compounds 



768 Toxin of Helminthosporium victoriae. 



This toxin consists of two loosely connected moieties. 

 The first is a tricyclic secondary amine called victoxinine, 

 and the second a pentapeptide. The intact toxin shows a 

 negative ninhydrin test, and a molecular weight of 800 

 was assumed. 



Victoxinine, C,-Ho,,ON (Hydrochloride), colorless nee- 

 dles, m.p. 172°, [a],r' -78° (c 3.2 in 95% alcohol). 

 Negative U.V. 



Pentapeptide : 



On acid hydrolysis yielded: 

 Aspartic acid, glutamic acid, glycine, valine and one of 

 the leucines. 



Helminthosporiinn victoriae 



Ross B. Pringle and Armin C. Braun, Nature 181 1205 

 (1958). 



769 Telomycin, cream colored amorphous solid. 



A polypeptide antibiotic, containing glycine, alanine, 

 threonine and aspartic acid. Molecular weight about 

 1000. Contains no sulfur. Negative Fehling, ninhydrin, 

 biuret. Similar to etamycin. 



Streptomyces sp. 



M. Misiek, O. B. Fardig, A. Gourevitch, D. L. Johnson, I. R. 

 Hooper and J. Lein, "Antibiotics Annual 1957-1958," Medical 

 Encyclopedia, Inc., New York, p. 852. 



770 Etamycin (Viridogrisein), C44H6oOi,.N,s, white crystals, hydro- 



chloride m.p. 163-170° (dec), [a]ir' conflicting reports. 



HO, 

 O 



\ ^^C -^"^CH^ / 

 CH3 CH ^CH 



/N Sore \^ 



o 



P NH CH, 



/ \ ^ ^ 



CHj— CH L-Ala D-Leu CM— CH2 ^H 



I 1 ^"' 



NH C=o 



\ I 



" \ OH-Pro / CH, 



CH 3,N-DIMe CH \ 



C\ Ch' X^ Leu Sore ^ CH"^"^ 



CH CH, / C- CH ^^ Au 



/ ^"^ CH3 // ^"^ \ O OH 



CHj o CH, 



