Pfizer Handbook of Microbial Metabolites 



368 



Streptomyces sp. resembling S. lavendulae 



Cf. Pyridomycin staphylomycin, osteogrycin, PA-114, 

 mikamycin, streptogramin, telomycin, echinomycin. 



This class of polypeptides appears to be related bi- 

 ogenically to the actinomycins. 



B. Heinemann, A. Gourevitch, J. Lein, D. L. Johnson, M. A. 

 Kaplan, D. Vanas and I. R. Hooper, "Antibiotics Annual 1954— 

 1955," Medical Encyclopedia, Inc., New York, p. 728. 



Quentin R. Bartz, Jean Standiford, James D. Mold, Doris W. 

 Johannessen, Albert Ryder, Andrew Maretzki and Theodore H. 

 Haskell, ibid., p. 777. 



Theodore H. Haskell, Andrew Maretzki and Quentin R. 

 Bartz, ibid., p. 784. 



John C. Sheehan, Hans Georg Zachau and WiUiam B. Law- 

 son, /. Am. Chem. Soc. 79 3933 (1957). (Structure) 



771 Colistin, C4gH850ioNi3. 



CH3 



CH3 



\ 



I 



/ 



co- 



NHo 



CH2 

 I 

 CH2 



I 

 -CH- 



-NH.^ 



CHCH2 NH' 



CO 



/ 



NH 

 HaNCHjCrij— CH 



I 



CO 



\ 



NH 



i-Diamino- ^CO CH2CH2NH2 



butyric Acid \^ / 



CH 

 D-Leucine L-Diamino- \ 



butyric Acid \li 



\ 



CO 



l-Diaminobutyric \ 



Acid CH — CH0CH2NH2 



NH 



/ 



aminobutyric 

 Acid 



CH3 



L-Leucine 



\ 



CH 



CHCHf 



CO. 



L-Diaminobutyric 

 Acid 



L-Threonine CO 



/ 



CH 

 NH CH 



OH 



-NH 



CO' 



\ 



CH3 



CH3 



-CH- 



] 

 CHo 



I 

 CH2 



I 



NH— CO(CH2)4CHCH2CH3 

 I 

 CHs 



Yasuo Koyama, Akio Kurosasa, Atsushi Tsuchiya and Kin- 

 suke Takakuta, J. Antibiotics (Japan) 3 457 (1950). 



