Pfizer Handbook of Microbial Metabolites 372 



group. There may be other similar compounds in the 

 complex also. 



F. J. Murray, P. A. Tetrault, O. W. Kaufman, H. Koffler, 

 D. H. Peterson and D. R. Colingsworth, J. Bad. 57 305 

 (1949). 



D. H. Peterson and L. M. Reineke, J. Biol. Chem. 181 95 

 (1949). 



Tashio Kobayashi, J. E. Grady, J. L. Parsons, Henry Koffler 

 and P. A. Tetrault, Abstr. 133rd Meeting Am. Cheyn. Soc, 25C 

 (1958). 



H. Koffler and T. Kobayashi, Abstr. 4th Intern. Congr. 

 Biochem., 9 (1958). 



Henry Koffler, Science 130 1419 (1959). 



778 Fungisporin, Cr.gHyoOgNg, colorless crystals, m.p. 355-360° 

 (dec.) (subl. from 250°), molecular weight 980. 

 Proposed structure: 



CHs CH3 



CH O 



O 1 // CH3 



\ X D-Valine \ / \ 



CH L-Phenyl- CH CH3 



// alanine L-Valine \ q 



NH C^ 



=C NH 



/ '^— CH2— CH D-Phenyl- D-Phenyl- CH— CH.— '^^^ 



1 alanine alanine I 



NH C^^ 



\ / ° 



^C NH 



O^ \ L-Valine L-Phenyl- / 



CH3 CH alanine CH 



CH 



\ / \ D-Valine _/^ \ 



CH NH. Xf Yh 



^C-^CH—NH-^X CH. 



// I o 



O CH 



/ \ 

 CH3 CH3 



Penicillium and Aspergillus spp. 



This polypeptide was obtained by destructive distilla- 

 tion of spores, when it separated by sublimation. 



