Pfizer Handbook of Microbial Metabolites 378 



788 Gramicidin S (Gramicidin C), CeoHgoOioNio, colorless needles, 

 m.p. 277° (dec), [2;]..'' -289° ±10° (c 0.43 in 70% etha- 

 nol). 



CH 



CH2 



CO— NHCHCO— NHCHCO— NHCHCO— NHCHCO— N CHo 



I (l) (l) (l) (d) 

 CH,— CH 



[l) (l) CH— CH'2 



(d) (l) (l) (l) 1 



CH2— N COCHNH— COCHNH— COCHNH— COCHNH— CO 



I I I 1 



CH. CHo CH2 CH 



I I I / \ 



CH CH, CHs CHs 



/ \ 1 



CHs CHs CH2 



I 

 NH2 



Bacillus brevis var. Gause-Brazhnikova 



G. F. Cause and M. G. Brazhnikova, Am. Rev. Soviet Med. 

 2 134 (1944). 



R. L. M. Synge, Biochem. }. 39 363 (1945). (Character- 

 istics) 



F. Sanger, ibid. 40 261 (1946). 



R. Consden, A. H. Gordon, A. J. P. Martin and R. L. M. 

 Synge, ibid. 40 xciii (1946). 



Idem., ibid. 41 596 (1947). 



Alan R. Battersby and Lyman C. Craig, /. Am. Chem. Soc. 

 73 1887 (1951). 



R. Schwyzer and P. Sieber, Helv. Chim. Acta 40 624 (1957). 

 (Synthesis) 



789 Gramicidin D (Gramicidin Dubos), colorless crystals, m.p. 229° 

 (dec). 



A crystalline component of tyrothricin. A cyclic poly- 

 peptide composed of 4 moles of D-Leucine, 4 moles of l- 

 tryptophan, 2 moles of o-Valine, 2 moles of L-Valine, 2 

 moles of L-alanine, 1 mole of glycine and 1 mole of 

 ethanolamine. 



Bacillus brevis 



Rene J. Dubos and Rollin D. Hotchkiss, J. Exptl. Med. 73 

 629 (1941). (Isolation) 



A. H. Gordon, A. T. P. Martin and R. L. M. Synge, Biochem. 

 J. 37 86 (1943). 



