Pfizer Handbook of Microbial Metabolites 



390 



814 Bacitracin A, CeeHiogOigN^yS, white, hygroscopic, amorphous 

 powder, [a]i,'' +5° (±2.5°). 



CH3 



/ 



CH2 



CHo 



\ 



NH2 



CH3 



Bacillus subtilis, B. licheniforTnis 



The bacitracins are a difficultly separable polypeptide 

 complex. Bacitracins A, B, C, D, E, F^, F^, F;^ and G have 

 been differentiated. The F series may be artifacts. The 

 structure of bacitracin A has received the most attention. 

 In certain of the other bacitracins isoleucine is replaced 

 by valine. The complex from B. liche7iiformis was origi- 

 nally called ayfivin. 



I. M. Lockhart, E. P. Abraham and G. G. F. Newton, 

 Biochem. J. 61 534 (1955). 



J. R. Weisiger, W. Hausmann and L. C. Craig, /. Am. Chem. 

 Soc. 77 731, 3123 (1955). 



Dorothy Wrinch, Nature 179 536 (1957). 



E. P. Abraham, "CIBA Lectures in Microbial Biochemistry," 



