393 Polypeptides and Related Compounds 



824 Comirin, nearly colorless powder, m.p. 230-235° (dec.)- 



A polypeptide containing the following amino acids: 

 serine, aspartic acid, glycine, a,y-diaminobutyric acid, 

 lysine, leucine, isoleucine, tyrosine and arginine. An 

 ether-soluble moiety also was present. Negative ninhy- 

 drin, positive biuret. No free amino acid groups. 

 Pseudomonas antimycetica 

 W. G. C. Forsyth, Biochem. J. 59 500 (1955). 



825 Colimycin. 



A crystalline polypeptide, containing mainly D-leucine 

 and L-threonine. 

 Bacillus colistinus 

 P. V. Forni and E. Guidetti, Minerva med. II 823 (1956). 



826 Brevin. 

 Brevin is a polypeptide containing: aspartic acid, gly- 

 cine, tyrosine, serine, an unidentified basic substance 

 (and also a fatty acid component?). 



Bacillus brevis 



I Ella M. Barnes and G. G. F. Newton, Antibiotics and Chem- 



otherapy 3 866 (1953). 



827 Brevolin, Hydrochloride yellowish white amorphous, [ajn^*' 



-18.9°. 



Brevolin is a polypeptide, probably related to brevin. 



Bacillus brevis 



Junichi Kawamata and Yutaka Motomura, J. Antibiotics 

 (Japan) 7A 25 (1954). 



Antibiotics from Yeast. 



Two amorphous compounds have been isolated from 

 bakers' yeast. They have antibacterial and antifungal 

 effects, and seem to be cyclic polypeptides. Acid hydroly- 



828 sis of one of these (Y^) gave leucine, valine, alanine, 



829 glutamic acid and glycine. Acid hydrolysis of Y2 gave the 

 same amino acids plus y-aminobutyric acid. 



■ Werner Motzel and Elton S. Cook, Nature 182 455 (1958). 



F ,, . 



830 Alvem. 



A basic polypeptide containing arginine. 

 Bacillus alvei 



K. Gilliver, A. M. Holmes and E. P. Abraham, Brit. J. 

 Exptl. Path. 30 209 (1949). 



