413 Pyrans and Related Substances 



Peuicillium frequentans, P. roseo-purpurogenum, P. gla- 

 brum, P. pfefferianuvi, Citromyces strains, Corynebacte- 

 rium diphtheriae 



A. C. Hetherington and H. Raistrick, Trans. Roy. Soc. (Lon- 

 don) B220 209 (1931). (Isolation) 



Alexander Robertson, W. B. Whalley and J. Yates, /. Chem. 

 Soc, 2013 (1951). (Structure) 



Michizo Asano and Hideo Takahashi, /. Pharm. Soc. Japan 

 65 81 (1945). (Isolation from the corynebacterium ) 



874 Purpurogenone, Ci4H]oO,r,, crimson prisms, m.p. 310° (dec). 



OH OH 



Penicillium purpurogenum StoU 



Yield 8-14 g. of crude pigment from about 250 g. of dry 

 mycelium, which was obtained from about 70 liters of 

 culture solution. 



Ergosteryl palmitate, m.p. 104-106°, and mannitol, 

 m.p. 166°, also were isolated from this fermentation. 



John C. Roberts and C. W. H. Warren, ]. Chem. Soc, 2992 

 (1955). 



875 Fulvic Acid, C14H12OS, yellow crystals, m.p. 246° (dec). 



HO OH 



Penicillium flexuosum, P. brefeldianum, P. griseofulvum 



876 P. griseofulvum produced a nitrogen-containing com- 

 pound, m.p. 165°, in the same broth. P. brefeldianum, 



877 produced a neutral nitrogen-containing compound, m.p. 

 132-135°, in the same culture. 



Albert Edw. Oxford, Harold Raistrick and Paul Simonart, 

 Biochem. J. 29 1102 (1935). (Isolation) 



F. M. Dean, R. A. Eade, R. A. Moubasher and A. Robertson, 

 Nature 179 366 (1957). (Structure) 



