Pfizer Handbook of Microbial Metabolites 



414 



878 Fuscin, CisHipOg, orange plates, m.p. 230°. 



O 



CH3 



.0 



HO 



-^N^N CH3 

 CH3 



879 



Oidiodendron fuscum Robak 



A colorless dihydrofuscin, m.p. 206°, was also produced. 

 S. E. Michael, Biochem. J. 43 528 (1948). (Isolation) 

 D. H. R. Barton and J. B. Hendrickson, J. Chem. Soc, 1028 

 (1956). (Synthesis) 



Azaphilones. 



This group of mold pigments, so named because most of 

 them react avidly with ammonia, includes monascorubrin, 

 sclerotiorin, rotiorin, rubropunctatin and monascin. 



A. Powell, A. Robertson and W. Whalley, "Chemical Society 

 Symposia," Special Publication No. 5, The Chemical Society, 

 London, 1956, p. 27. (Survey of the chemistry of the azaphi- 

 lones to that date) 



880 Rubropunctatin, C2iHo^0-,, orange needles, m.p. 156.5° (dec), 

 [a],. -3481° "(c 1.07 in chloroform). 



CH3CH2CH,CH,CH2— C=0 



I 



* CH3\ 



CH=CH— CHa 



0=Cs 



Monascus rubropunctatus Sato 



E. J. Haws, J. S. E. Holker, A. Kelly, A. D. G. Powell and 

 Alexander Robertson, /. Chem. Soc, 3598 (1959). (Structure) 

 A. Powell, Dissertation, Liverpool, 1954. (Isolation) 



881 Sclerotiorin, CoiHooO-.Cl, yellow crystals, m.p. 206° [a]„ +500°. 



CI CH3 CH3 



CHs— C 



CH2CH3 



