Pfizer Handbook of Microbial Metabolites 416 



H. Nishikawa, /. Agr. Chem. Soc. Japan 5 1007 (1932). 

 (Isolation) 



K. Nakanishi, M. Ohashi, S. Kumasaki and S. Yamamura, 

 J. Am. Chem. Soc. 81 6339, 6340 (1959). (Structure) 



B. C. Fielding, E. J. Haws, J. S. E. Holker, A. D. G. PoweU, 

 A. Robertson, D. N. Stanway and W. B. Whalley, Tetrahedron 

 Letters No. 5 24 (1960). (Proposed revised structure shown) 



885 Novobiocin (Streptonivicin, Cathomycln, Albamycin, Sphero- 

 mycin, Vulcamycin, Crystallinlc Acid, Antibiotic PA-93, 

 Cardelmycin), C31H36O11N2, pale yellow crystals, m.p. 

 152-156° (dec.) and 174-178° (dec.) (polymorphic), 

 [aJD^* -63° (c 1 in ethanol). 



HoN— C 



Streptomyces spheroides, S. niveus, S. griseus 



Herman Hoeksema, James L. Johnson and Jack W. Hin- 

 man, J. Am. Chem. Soc. 77 6710 (1955). 



Jack W. Hinman, Herman Hoeksema, E. Louis Caron and 

 W. G. Jackson, ibid. 78 1072 (1956). 



Clifford H. Shunk, Charles H. Stammer, Edward A. Kaczka, 

 Edward Walton, Claude F. Spencer, Andrew N. Wilson, 

 John W. Richter, Frederick W. HoUy and Karl Folkers, ibid. 

 78 1770 (1956). (Structure) 



Herman Hoeksema, E. Louis Caron and Jack W. Hinman, 

 ibid. 78 2019 (1956). (Structure) 



d. XANTHONES 

 886 Ravenelin, C14H10O5, yellowish crystals, m.p. 267°. 



OH O OH 



