Pfizer Handbook of Microbial Metabolites 424 



O O 



II II 



CH3— C=CH— C— CoA ^ HOOC— CH2— C=CH— C— CoA 24, 25 



CH3 CH3 



/3-Methylcrotonyl CoA /3-Methylglutaconyl CoA 



o o 



II II 



CH3CH2C— CoA ;:± HOOC— CH2—CH2—C— CoA 

 Propionyl CoA Succinyl CoA 



26.27 



COOH 28, 29 



I 



CH2 o 



/N I H /- 



HC^ \ CH— N— C 



II CH aspartic acid | \ ^j 



C\,/ — -p >COOH C-^X 



/ V CO2 II CH 



Ribose phosphate / N 



Ribose phosphate 



(Intermediates in purine biosynthesis) 



O O 30 



II II 



CH3— C— CoA ;;::± HOOC— CH2—C— CoA 

 Acetyi-CoA Malonyl-CoA 



1^ William Shive and Lorene Lane Rogers, ibid. 169 453 (1947). 



20 Herman C. Lichstein and W. W. Umbreit, ibid. 170 329 (1947). 



21 Henry A. Lardy, Richard L. Potter and R. H. Burris, ibid. 179 721 

 (1949). 



22 Patricia R. MacLeod, Santiago Grisolia, Philip P. Cohen and 

 Henry A. Lardy, ibid. 180 1003 (1949). 



"3 Gladys Feldott and Henry A. Lardy, ibid. 192 447 (1951 ). 



2* Bimal K. Bachhawat, Wm. G. Robinson and Minor J. Coon, 

 ;. Am. Chem. Soc. 76 3098 (1954); idem., J. Biol. Chem. 219 539 

 (1956). 



^^ F. Lynen, J. Knappe, E. Lorch, G. Jutting and E. Ringelmann, 

 Angew. Chem. 71 481 (1959). 



'*^ Henry A. Lardy and Robert Peanasky, Physiol. Rev. 33 560 

 (1953). 



-' Henry A. Lardy and Julius Adler, /. Biol. Chem. 219 933 (1956). 



28 Patricia R. MacLeod and Henry A. Lardy, ibid. 179 733 (1949). 



2^ Albert G. Moat, Charles N. Wilkins, Jr. and Herman Friedman, 

 ibid. 223 985 (1956); Albert G. Moat and Floyd Nasuti, Federation 

 Proc. 19 313 (1960). 



