429 



Thiophenes, Imidazoles, Thiazoles, Isoxazoles 



898 5-Amino-4-imidazolecarboxamide Riboside, CoHi40r,N4, colorless 

 crystals, m.p. 213° (dec, previous browning). 



II 



HOCH 



OH OH 



Escherichia coli (sulfonamide— inhibited) 

 G. Robert Greenberg and Edra L. Spilman, /. Biol. Chem. 

 219 411 (1956). 



899 Actithiazic Acid (Acidomycin, Mycobacidin PA-95), CyHigOgNS, 

 colorless needles, m.p. 140°, [aJD'^ —60° (c 1 in absolute 

 alcohol). 



o=c- 



-NH 



CH2 



CH— CH2CH2CH2CH2CH2COOH 



Streptomyces virginiae, S. cinnamonensis, S. lavendu- 

 lae 



Yields of about 0.3 g. per liter have been reported. 



Walton E. Grundy, Alma L. Whitman, Elbina G. Rdzok, 

 Edward J. Rdzok, Marjorie E. Hanes and John C. Sylvester, 

 Antibiotics and Chemotherapy 2 399 (1952). 



J. R. Schenck and A. F. DeRose, Arch. Biochem. and 

 Biophys. 40 263 (1952). 



R. K. Clark, Jr. and J. R. Schenck, ibid. 40 270 (1952). 



W. M. McLamore, Walter D. Celmer, Virgil V. Bogert, Frank 

 C. Pennington and I. A. Solomons, /. Am. Chem. Soc. 74 2946 

 (1952). 



B. A. Sobin, ibid. 74 2947 (1952). 



W. M. McLamore, Walter D. Celmer, Virgil V. Bogert, Frank 

 C. Pennington, B. A. Sobin and I. A. Solomons, ibid. 75 105 

 (1953). (Synthesis) 



