431 Thiophenes, Imidazoles, Thiazoles, Isoxazoles 



902 Dethiobiotin (Desthiobiotin, 5-Methyl-2-oxo-4-imidazolidineca- 

 proic Acid), C,,,H,,sO;(No, colorless needles, m.p. 156-158°, 

 [all,-' +10.7° (c 2.0 in water). 



HN NH 



CHs (CHolsCOOH 



Penicillium chrysogenum 



E. L. Tatum, 7. Biol. Chem. 160 455 (1945). 



903 Thiamin (Vitamin B,, Aneurin) (Chloride Hydrochloride), 



Ci.HjsOi\4CLS, colorless needles, m.p. ~250° (dec). 



NHoHCI CHs CHoCHoOH 



CHo \ / 



CI® 



Most yeasts, molds and bacteria 



Yields of 120-200 /xg. per gram of dry primary-grown 

 yeast cells can be obtained. Much higher yields (600- 

 1200 /xg. per gram) can be obtained if all that is required 

 is coupling of supplied precursors. 



Leland A. Underkofler and Richard J. Hickey, "Industrial 

 Fermentations," Chemical PubHshing Co., Inc., New York, 

 1954 Vol. II, J. M. Van Lanen Production of vitamins other 

 than riboflavin, chap. 6, pp. 191-216. (A review) 



904 Cocarboxylase (Cozymase II, Vitamin Bi-diphosphate, Thiamin 



diphosphate, Aneurindiphosphate) (Hydrochloride), 

 Ci^HisO-N^SP.-HCl, nearly colorless needles, m.p. 242- 

 244° (dec). 





 C— CHs O O 



CH C— CH2— CH2— O— P— O— P=0 



I I 



OH OH 



