461 



Indoles 



H,N^\ 



COOH 



Phenylalanine 



lO] 



H-iU^^ 



Serine 



COOH Methionine 

 m-Tyroslne 



XH3 

 CH2OH 



''from Serine^ 



and 

 ^Methionine 

 Dethiogiiotoxin 



2S 



N s 

 s N 



,/- 



CH2OH 

 Gliotoxin 



Methionine was the most efficient source of the N-methyl 

 group, the ^-carbon of serine being about one third as ef- 

 fective. Both of the amino acid skeletons were incorpo- 

 j rated intact when furnished, and m-tyrosine could also be 



used as a precursor. 



, 933 Indole, CgHyN, colorless leaflets, m.p. 52°. 



cxj 



934 



H 



Escherichia coli mutants, yeasts, Treponema spp. 



P. A. Trudinger, Biochem. J. 62 480 (1956). 



Charles Yanofsky, /. Biol. Chem. 223 171 (1956). 



F. Gibson, Marjorie J. Jones and H. Teltscher, Biochem. J. 

 64 132 (1957). 



L. W. Parks and H. C. Douglas, Biochim. et Biophys. Acta 

 23 207 (1957). 



Michel Moureau and W. Aladame, Ann. inst. Pasteur 88 231 

 (1955). 



Indole-3-acetic Acid (Rhizopin), CioHgOoN, colorless plates, m.p. 

 164°. 



oa 



CHoCOOH 



Rhizopus suinus, R. nigricans, Aspergillus niger, Peni- 



