467 



Ergot Alkaloids 



A number of different hypotheses have been advanced 

 concerning the biosynthetic origin of the ergot alkaloids. 

 These are outlined below: 

 ( 1 ) van Tamelen ( 1 953 ) : * 



HO 



r^ 



; 



CHo— CH— COOH 



NH2 



cXj 



lO] o^ 



CH — CH— COOH 



' ' I 



NH2 + 



I 

 CH3 



CONHo 



CHo— CH— COOH 



I 

 NH2 



CH>— CH— COOH 



I 

 NHo 



CONHo 



CH2— COOH 



© 



— H2 



< 



CONH2 



I 



N— CH3 



— CO2 ^ 



N 

 H 



i 

 Lysergic Acid 



(2) Harley-Mason (1954):^ 



Eugene van Tamelen, Experientia 9 457 (1953). 

 'J. Harley-Mason, Chem. and Ind., 251 (1954). 



