Pfizer Handbook of Microbial Metabolites 488 



may be that it serves a structural or other function here. 



D-Cycloserine has been reported to inhibit aspartate 

 aminopherase, indole synthetase and D-alanine-D-gluta- 

 mate aminopherase in some bacteria.-^' ^° Aspartic ana- 

 logues, such as diaminosuccinic acid and hydroxyaspartic 

 acid also are effective inhibitors of the first enzyme 

 above. ^^ 



It has been suggested that pyridoxine may be impli- 

 cated in the active transport of amino acids across cell 

 walls. ^^ 



968 2, 6-Dipicolinic Acid, C7H5O4N, colorless needles, m.p. 236° 



(dec). 



HOOC COOH 



Bacillus megatherium, B. cereus var. terminalis, B. 

 sphaericus types 



Occurs as the calcuim salt in spores. 



Joan F. Powell, Biochem. J. 54 210 (1953). 



William K. Harrell and Emil Mantini, Can. J. Microbiol. 3 

 735 (1957). 



Joan F. Powell and R. E. Strange, Biochem. J. 65 700 

 (1957). 



969 Pyridoxal-5'-phosphate CgHioOgNF 



O 



OH 



HO I CH2— O— P=0 



OH 



>N 



CH3 

 Yeasts, molds, bacteria (widely distributed) 



29Takakazu Aoki, Kekkaku 32 544, 605 (1957). (Chem. Ahstr. 52 

 7427g). 



30 N. K. Kochetkov, R. M. Khomutov, M. J. Karpeiskii, E. I. Budov- 

 skii and E. S. Severin, Doklady Akad. Nauk S.S.S.R. 126 1132 (1959). 



3^ Mario Garcia-Hernandez and Ernest Kun, Biochim. et Biophys. 

 Acta 24 78 (1957). 



3- Halvor N. Christensen, Thomas R. Riggs and Barbara R. Coyne, 

 J. Biol. Chem. 209 413 (1954); Halvor N. Christensen and Thomas R. 

 Riggs, ibid. 220 265 (1956). 



