Pfizer Handbook of Microbial Metabolites 



530 



The general scheme of purine biosynthesis is under- 

 stood now. It is outlined in the following equations :" 



O3POCH2 



OH OH 



Ribose-5- 

 phosphate 



ATP AMP O3POCH2 o 

 OH Mg^H) 



OPocS 



Glut- Glut- 

 amine amate 



V ^ 



Mg<S> 



OH OH 

 Ribose- 1 -pyrophos- 

 phate-5-phosphate © 



NH3 



/ 

 CH2 



a 



03POCH2 



Glycine ADR 



+ +©fi 



NH. ATP HPO4 O3POCH2 



c=o 



I 

 NH 



OH OH 

 1-Aminoribose- 

 5'-phosphate 



OH OH 



Glycinamide 

 Ribotide 



H2O 



CH2 CHO 



N\Ni°-Anhydro- 

 - formyl THFA 



■— ^THFA 

 .NK 



© I 

 H2N=C 



a 



Glut- Glut- 

 note amii 

 k Mg(H>; 



CH. 



c=o 



CHO 



'O3POCH0 r. NH amate amine ""O3POCH2 ^ NH 



OH OH ADP ATP 



Formylglycin- HPO4© H;0 



amidine Ribotide 



OH OH 



Formylglycin- 

 amide Ribotide 



H2O ^1 ^^ ATP 

 HP04Q^^^-^ADP 



" Reproduced from reference 20. 



