537 



Purines 



11 



o o 



T T 



CHo— O— P— O— P— O— CH2 

 OH OH 



CH3 OH O 



I I II 

 -C CH— C— NH 



CH3 I 



CH2 



I 

 CH2 



HSCH2— CH2— NH— C=0 

 3'-Dephosphocoenzyme A 



i ATP 



Coenzyme A 



Most of these intermediates have been identified in mi- 

 croorganisms, e.g. Streptobacterium plantar urn. '-^^ Pan- 

 tothenic acid is required by some microorganisms, but 

 probably not by man, perhaps because of the excess pro- 

 duced by E. coli and other intestinal microbes. 



A number of higher fungi and molds have been ex- 

 amined thoroughly for nucleotide content. Some of the 

 organisms which have been studied are: Penicillium 

 chrysogenum,^* Aspergillus oryzae/'' Polyporus squamo- 

 sus,^^ Amanita muscaria,^^ Lycoperdon pratense,^^ 

 Hypholoma capnoides/'^ Armillaria mellea,^^ Pholiota 

 squarrosa,^'^ Lactarius vellereus,^''' Lactarius turpis,^'^ Toru- 

 lopsis utilis,^'' Micrococcus lysodeikticus,^^ Coprinus co- 

 matis,^^ and Polyporus sulfureus.*^ 



^3 Theodor Wieland, Walter Maul and Ernst Friedrich Moller, 

 Biochem. Z. 327 85 (1955). 



^* A. Ballio, C. Casinovi and G. Serlupi-Crescenzi, Biochim. et 

 Biophys. Acta 20 414 (1956); Alessandro Ballio and Giovanni Serlupi- 

 Crescenzi, Nature 179 154 (1957). 



^^ Kazuo Okunuki, Kozo Iwasa, Fumlo Imamoto and Tadoyoshi 

 Higashiyama, J. Biochem. (Tokyo) 45 795 (1958). 



3«Rolf Bergkvlst, Acta Chem. Scand. 12 1549, 1554 (1958). 



37 D. Gilbert and E. Yemm, Nature 182 1745 (1958). 



38 J. V. Scaletti, Dissertation Abstr. 17 1191 (1957). 



39 Paul Heinz List, Arch. Pharm. 291 502 (1958). 

 *°ldem., Planta Med. 6 424 (1958). 



