Pfizer Handbook of Microbial Metabolites 



562 



s 

 u 



B 



/" 



^iSH 



Jx <— dpnh4x 





>'r> 



+ 



H 



The natures of the entities X, Y and Z are mysterious. If 

 they are assumed to possess nucleophiUc groups such as 

 R — S', R — COO" or H0PO4", then one scheme has been ad- 

 vanced to show how the requisite energy-rich bonds could 

 be formed in DPNH, FADH and Ferricytochrome ag.^" 

 The couphng methods and resonance systems involved are 

 shown in the diagram: 



CHj 



H Hilll 

 Rb-ADP 



H H -K 



/ +HX;=; r 'J; ^N; + oh© 



^N 



Rb-ADP 



C H 



N +2e -f- HjO 



H % (3. 



I ill! " 



^0(2) 



CHj 1 r ^>ri,„ CH: 



ADP-Rb H 

 (1) 



H X 





HC— X 



CjHs CH; 



CH Fe(3) CH + HX 



fatty CH 



acid II 



RCH 



ADP-Rb ^) 



+2e + H2O 



CH— 



-f-OHQ— a 



Z 



OH 



R— C -t- HS— E ;^ R— C— SE -> R— C -f 2e -f- 2H© 



\ I \ 



H H SE 



5" Paul E. Glahn and Sigurd O. Nielsen, Nature 183 1578 (1959). 



