Pfizer Handbook of Microbial Metabolites 570 



Yeasts, molds, bacteria (widely distributed) 



Otto Warburg and Walter Christian, Biochem. Z. 298 150 



(1938). (Isolation) 



S. M. H. Christie, G. W. Kenner and A. R. Todd, Nature 170 



924 (1952). 



Idem., J. Chem. Soc, 46 (1954). (Synthesis) 



J. G. MofFatt and H. G. Khorana, /. Am. Chem. Soc. 80 



3756 (1958). (Synthesis) 



1061 Fermentation "Lactobacillus casei" Factor (Teropterin, Pteroyl-y- 

 glutamyl-y-glutamylglutamic Acid), C29H33O12N9. 



CH2— NH— <f \— CO— NH— CH— COOH 



{CH,)2 



V '-" 



H2N CO 



NH 

 HOOC(CH2)2— CH— NH— CO— (CHo)^— CH— COOH 

 COOH 



Corynebacterium sp. 



Brian L. Hutchings, E. L. R. Stokstad, Nestor Bohonos, Na- 

 than Sloane and Y. Subbarow, Ann. N. Y. Acad. Sci. 48 265 

 (1946). (Isolation) 



J. H. Boothe, J. H. Mowat, B. L. Hutchings, R. B. Angler, 

 C. W. Waller, E. L. R. Stokstad, J. Semb, A. L. Gazzola and 

 Y. Subbarow, /. Am. Chem. Soc. 70 1099 (1948). 



J. H. Boothe, J. Semb, C. W. Waller, R. B. Angler, J. H. 

 Mowat, B. L. Hutchings, E. L. R. Stokstad and Y. Subbarow, 

 ibid. 71 2304 (1949). (Synthesis) 



1062 Vitamin Bg Conjugate (Pteroylhexaglutamyl glutamic Acid), 



C4oHoiOo4Ni3. 



The structure is like that of the preceding formula, but 

 with four more glutamic acid units in the polypeptide side- 

 chain. 



Bacteria, yeasts, molds (widely distributed among 

 microorganisms ) 



P. R. Burkholder, Ilda McVeigh and Katherine Wilson, 

 Arch. Biochem. 7 287 (1945). 



J. J. Pfiffner, D. G. Calkins, E. S. Bloom and B. L. O'Dell, 

 J. Am. Chem. Soc 68 1392 (1946). (Structure) 



