Pfizer Handbook of Microbial Metabolites 586 



Streptomyces lactis 



A. E. Oxford, Biochem. 7. 38 178 (1944). 



Idem., ibid. 39 xiii (1945). 



1146 Distamycin A, pure white powder, basic, forms salts. 



Positive biuret test. 



CIBA, Australian Patent 28,469 (1957). 



1147 D-Substance, white needles, m.p. 124-125°. 



Highly toxic. 



Streptomyces flavus 0-2 



Isao Takahashi, /. Antibiotics (Japan) 6A 117 (1953). 



1148 Elaiophylin (C^HioOo),,, no N, S, X, white crystals, m.p. 178- 



183° (dec.) [air'' -49° (in chloroform). 



Streptomyces melanosporus (sine melanosporofaciens) 

 F. M. Arcamone, C. Bertazzoh, M. Ghione and T. Scotti, 



Giorn. microbiol. 7 207 (1959). 



1149 Endosubtilysin, yellow powder, soluble in alcohol and chloro- 



form. Forms a water-soluble sodium salt. Appears to 

 be an organic acid. 



Bacillus subtilis 



Louis de Saint-Rat and Henry R. Olivier, Compt. rend. 222 

 297 (1946). 



1150 Enteromycin, m.p. 167-168°, U.V. 282 m,x. 



C 38.2, H 4.62, N 4.3. 



Streptococcus albireticuli 



Teisuke Osato, Masahiro Ueda, Setsuko Fukuyama, Koki 

 Yagishita, Yoshiro Okami and Hamao Umezawa, /. Antibiotics 

 (Japan) 8A 105 (1955). 



1151 Ergochrysin, CosHosOjo, yellow-golden leaflets, m.p. 266° from 



chloroform (242-244° from alcohol-pyridine). 

 Claviceps purpurea 



C. Jacoby, Arch. exp. Pathol. Pharmakol. 39 85 (1897). 

 Werner Bergmann, Ber. 65 1486, 1489 (1932). 



1152 Ergoflavin, C3oH2fjO,4, yellow needles, m.p. 350° (dec.) from 



methanol or dioxane, [a]i,-' +37.5° (c 1.236 in acetone). 

 Structural features determined : 

 4 phenolic hydroxyls 

 2 alcoholic hydroxyls 

 2 carbonyls 

 2 y-lactones 

 Claviceps purpurea 



