Pfizer Handbook of Microbial Metabolites 590 



D. E. Ames, R. E. Bowman, J. F. Cavalla and D. D. Evans, 

 J. Chem. Soc, 4260 (1955). 



D. E. Ames and R. E. Bowman, ibid., 4264 (1955). 



1170 Helenine. 



An unstable, little characterized antiviral agent. A 

 ribonucleoprotein. 



Penicillium funiculosum 



Richard E. Shope, J. Exp. Med. 97 601, 639 (1953). 



U. J. Lewis, Edward L. Rickes, Laurella McClelland and 

 Norman G. Brick, J. Am. Chem. Soc. 81 4115 (1959). 



1171 Heliomycin, needles, chars >300°, complex U.V., Mol. Wt. 235. 



Positive FeClg and Millon. 

 May be a polypeptide. 



Actinomyces flavochromo genes var. heliomycini 

 M. G. Brazhnikova, T. A. Uspenskaya, L. B. Sokolova, T. P. 



Preobrazhenskaya, G. F. Gauze, R. S. Ukholina, V. A. Shorin, 



O. K. Rossolimo and T. P. Vertogradova, Antibiotiki 3 29 



(1958). 



1172 Hirsutic Acid C, Ci-,H.o04 (proposed), colorless crystals, m.p. 



179.5°, [cz]d'" +li.9° (in absolute ethanol). 



A group of acidic materials. Hirsutic acid C has been 

 best characterized. It is a monobasic acid, only slightly 

 soluble in H^-O, soluble in most organic solvents. Neg- 

 ative 2,4-DNPH, FeCl;^, Fehling. White precipitate with 

 Br water. 



Stereum hirsutum 



N. G. Heatley, M. A. Jennings and H. W. Florey, Brit. J. 

 Exp. Path. 28 35 (1947). 



1173 Hygroscopin A, C13H.4O3N., oil, b.p. 64° (0.003 mm.), ni.^^ 



1.4830, [a],," 84.7° (in methanol). 



1174 Hygroscopin B, Ci.-.Ho.O^N,, oil, b.p. 70° (0.008 mm.), n„^^ 



1.4935, [a],/' -38.8° (in ethanol). 



Streptoniyces hygroscopicus 



Koichi Nakazawa, Kinzo Oki, Isao Tadokoro, Mikio Honjo, 

 Hiroshi Hitomi and Jisaburo Ueyanagi, J. Agr. Chem. Soc. 

 Japan 28 296 (1954). 



Sueo Tatsuoka, Akira Miyake, Mikio Honjo, Hiroshi Hitomi, 

 Jisaburo Ueyanagi. Masuo Miyamoto, Koiti Nakazawa and 

 Kinzo Oki, J. Antibiotics (Japan) 7B 329 (1954). 



