Pfizer Handbook of Microbial Metabolites 594 



1190 Malucidin, complex yeast protein, soluble in water, not coagula- 



ble, not dialyzable. Contains organic phosphorus to 

 which its activity can be related. 



The protein is combined with RNA, while the latter by 

 itself has very little, if any, antibacterial property. 



Brewers' and bakers' yeasts 



I. A. Parfentjev, Federation Proc. 16 428 (1957). 



1191 Marasmic Acid, C10H00O4 (proposed) colorless needles, m.p. 



174° (sealed tube), [x]r>^^ 176° (c 1.4 in acetone). 



A monobasic acid with reducing properties. Negative 

 FeCl^, Br^ in CCI4. Forms a 2,4-dinitrophenylhydrazone. 



Marasmius conigenus 



Frederick Kavanagh, Annette Hervey and William J. Rob- 

 bins, Proc. Nat. Acad. Sci. U. S. 35 343 (1949). 



1192 Marcomycin, Ci-Ha^OyN:,, white crystals, m.p. 160-180° (dec). 



Streptomyces hygroscopicus 

 German Patent 1,027,846 (1958). 



1193 Megacidin, C24H38OJ0 (proposed), colorless crystals, m.p. 162- 



164°, [ain -51° (c 0.958 in ethanol). 



A neutral compound with an easily saponifiable ester 

 or lactone group. 



Also isolated from the same fermentation were: L-leu- 



1194 cyl-L-proline anhydride, m.p. 158-165°, [aln —128° (c 



1195 0.968 in ethanol) and L-leucyl-L-leucine anhydride. 



Streptomyces sp. 



L. Ettlinger, E. Gaumann, R. Hiitter, W. Keller-Schierlein, 

 F. Kradolfer, L. Neipp, V. Prelog, P. Reusser and H. Zahner, 

 Monatsh. Chem. 88 989 (1957). 



1196 Melanosporin, C56-63H105-117O20-22N3, yellowish white amorphous 



solid, m.p. 132-134°, [aW° +30° (c. 1.57 in methanol). 



Strong" acid hydrolysis yields three ninhydrin-positive 

 compounds. Negative FeClg. Positive ninhydrin. 



Streptomyces melanosporus {sine m,elanosporofaciens) 

 n. sp. 



F. M. Arcamone, C. Bertazzoli, M. Ghione and T. Scotti, 

 Giorn. microbial. 7 207 (1959). 



1197 Mesenterin, colorless needles, m.p. 122-126°. 



A basic compound, analysis: C 65.82, H 7.10, N 8.66. 

 Positive Molisch, negative ninhydrin, biuret, Fehling, 

 Feci,. 



