Pfizer Handbook of Microbial Metabolites 600 



Mol. Wt. = 424. Absorbs 2 moles H2. Four active H. 

 Five C — CH3 groups. Forms a diacetate. 



1233 Oligomycin B, C22H36O6, colorless crystals, m.p. 160°, 169° 



(polymorphic), [aW^^ —49.5° (c 1.03 in methanol). 

 Mol. Wt. = 396. Four active H. Five C— CH3 groups. 

 Forms a diacetate. 



1234 Oligomycin C, CorH^.-Oc colorless crystals, m.p. 198-200°, [aW^ 



-80.7° (c 3.70 in dioxane). 



Contains six C — CH3 groups. 



Streptomyces sp. (may be S. diastatochromo genes) 



Robert M. Smith, William H. Peterson and Elizabeth McCoy, 

 Antibiotics and Chemotherapy 4 962 (1954). 



Satoru Masamune, J. M. Sehgal, E. E. van Tamelen, F. M. 

 Strong and W. H. Peterson, /. Am. Chem. Sac. 80 6092 (1958). 



1235 Ophiobalin, C28H30O4, white prisms, m.p. 181-182°. 



Ophiobalus miyabeanus 



A. Neelameghan, Hindustan Antibiotics 2 13 (1959). 



1236 Oregonensin, C20H32OS (proposed), colorless needles, m.p. 82°. 



A neutral substance. Positive 2,4-DNPH. 



Ganoderma oregonense 



H. W. Florey, E. Chain, N. G. Heatley, M. A. Jennings, A. G. 

 Sanders, E. P. Abraham and M. E. Florey, "Antibiotics," Oxford 

 University Press, London, 1949, p. 362. 



1237 Oryzacidin (Oryzasizine), CgHigOsN, colorless, hygroscopic nee- 



dles, m.p. 162° (dec), [ajn -138°. 



y3-Nitropropionic acid also occurs free in the culture 

 broth. 



Aspergillus oryzae 



Chujiro Shimoda, /. Agr. Chem. Soc. Japan 25 254 (1951). 



Seiji Nakamura and Chuji Shimoda, ibid. 28 909 (1954). 



1238 PA-128, C37.46H6i.75O13.1cN, Ught yellow rectangular plates, m.p. 



143° [aln'' -2.0° (c 1 in methanol). 



Negative FeClg, no colors in aqueous base nor concen- 

 trated H2SO4. Positive 2,4-DNPH, decolorizes Brs water 

 and permanganate. Takes up >6 mM of hydrogen per 

 gram of antibiotic. 



Unclassified Streptomycete 



Koppaka V. Rao and John E. Lynch, Antibiotics and Chemo- 

 therapy 8 437 (1958). 



