Pfizer Handbook of Microbial Metabolites 602 



Isamu Hirose and Seiyo Aoe, Ann. Phytopathol. Soc. Japan 

 19 162 (1955). (Chem.' Abstr. 50 14058g) 



Isamu Hirose and S. Nishimura, Nippon Nogii-kagaku 

 Kaishi 30 528 (1956). 



1245 Piricularin, C17H14N2O3 or C18H14N0O3, colorless crystals, m.p. 



73.5°, [a]D'« -19°. 



Absorbs 4 moles of hydrogen over platinum catalyst, 

 contains two phenolic or enolic hydroxyls, no methoxyl. 

 Reacts with 3 moles of 2,4-dinitrophenylhydrazine. Has 

 1 N-methyl, no NH or NHo. A max. in HoO = 240 m/x. 

 Ejom/"^^ 2824. A toxin of rice blast disease. 



Piricularia oryzae 



Kinjiro Tamari and Jun Kaji, Nippon Nogei-kagaku Kaishi 

 31 387 (1957). 



1246 neomycin, C,4Hj20s, rectangular plates from ethanol, m.p. 



235°, U.V. 270, 330, 340 m^^ in 0.13 m phosphate buffer. 



Streptomyces pleofaciens 



Roy A. Machlowitz, Jesse Charney, Alfred A. Tytell and 

 W. P. Fisher, "Antibiotics Annual 1954-1955," Medical Ency- 

 clopedia, Inc., New York, p. 806. 



1247 Pleuromutilin (Drosophilin B), C22H340r,, colorless crystals, 



m.p. 170°, [aW +20° (c 3.0 in absolute ethanol). 



Forms a diacetate, non-phenolic, probably has a lactone 

 ring, forms a hydrazone. 



Pleurotus mutilus 



Marjorie Anchel, /. Biol. Chem. 199 133 (1952). 



1248 Pleurotin, C20H22O5, yellow-amber needles, m.p. 220-215° 



(dec), [a]v~^' —20° (c 0.59 in chloroform). 



A neutral, photosensitive compound. Negative FeCls, 

 oxidized KI. 



Pleurotus griseus 



William J. Robbins, Frederick Kavanaugh and Annette 

 Hervey, Proc. Nat. Acad. Sci. U. S. 33 171 (1947). 



1249 Pluramycin A, orange needle crystals, dec. from 177°, U.V. 208, 



245 (265-270) m^^ in ethanol. 

 C 66.63, H 6.30, N 3.66 

 Negative FeCl^, Fehling, ToUens and 2,4-DNPH. 



1250 Pluramycin B, reddish brown powder, possible neutral sub- 



stance. The pluramycins may be related to the actino- 

 mycins. 



