Pfizer Handbook of Microbial Metabolites 608 



Streptoinyces spectabilis 



Paul Siminoff, Robert M. Smith, Walter T. Sokolski and 

 G. M. Savage, Am. Rev. Tuherc. Pulmonary Diseases 75 576 

 (1957). 



George B. Whitfield, Edward C. Olson, Ross R. Herr, John A. 

 Fox, Malcolm E. Bergy and Gerald A. Boyack, ibid. 75 584 

 (1957). 



Upjohn Co., British Patent 811,757 (1959). 



1285 Streptozotacin, C14H17O12N5, m.p. 115-125° (dec). 



Probably still a mixture. Base-unstable neutral 

 substance. Seems to contain the partial structure 





 R — Cf /N=0. Alkaline treatment liberates diazo- 



^CH3 

 methane. 



Streptomyces achromogenes 



R. R. Herr, T. E. Eble, M. E. Bergy and H. K. Jahnke, 7th 

 Annual Symposium on Antibiotics, Washington, D. C, 1959. 



1286 Substance 1404, yellow crystalline, Hexaene. M.p. 210-220° 



(dec), [aln'' +67.5 ±2.0° (c 1 in dioxane). 

 Contains N 10.47, no sulfur, no halogen. 

 Streptomyces diastatochromogenes (Mycelium) 

 Masaji Igarashi, Koichi Ogata and Akira Miyake, J. Anti- 

 biotics (Japan) 8B 113 (1955). 



1287 Sulfactin, C3sH.-r,07NiiS4 or C27H4oO,-,NsS3 (proposed), hygro- 



scopic white needles, m.p. 245-275° (dec). 



Positive Fehling. Reduces KMn04. Negative biuret, 

 FeCl3, Molisch, Sakaguchi. 



Streptomyces roseus 



Renate Junowicz-Kocholaty, Walter Kocholaty and Albert 

 Kelner, J. Biol. Chem. 168 765 (1947). 



1288 Sulfocidin, yellow-brown crystals, m.p. 166-178°, [a]D^^ —58.5° 



(c 0.51 in chloroform). 



Neutral antibiotic, analysis C 64.88, H 8.38, N 4.25, S 

 1.80. Negative nitroprusside and azide iodine, ninhydrin, 

 FeCl3, Sakaguchi, maltol, biuret, Fehling, 2,4-DNPH. De- 

 colorizes permanganate. 



Streptomyces sp. 



Morris Zief, Robert Woodside and George E. Ham, "Anti- 

 biotics Annual 1957-1958," Medical Encyclopedia, Inc., New 

 York, p. 886. 



