ADDENDUM 



In order to cover pertinent literature appearing as late as 

 December, 1960 this addendum is attached. Also included is 

 a little material from earlier dates which was overlooked. Ar- 

 rangement is by chapter title, and new compounds eligible for 

 inclusion often are given appropriate entry numbers, but with a 

 letter added to the number so that it is evident in the indexes 

 that such entries are located in the addendum. Due to time 

 restrictions these entries may be abbreviated, but references are 

 listed. The addendum is not indexed. 



2. Alcohols, Glycols and Compounds Related to Sugars 



17a Acetyl Methyl Carbine! (Acetoin) 



This substance, mentioned as a co-product of butanediol, 

 is produced by many microorganisms. It is given off by 

 several streptomycetes, including Streptomyces erythreus, 

 an erythromycin producer. It is present in such large 

 quantities in some erythromycin fermentations that it 

 interferes with production of the antibiotic.^ 



A survey has been made of 44 species and strains of 

 acetobacter for ability to convert lactate to acetoin.^' A. 

 rancens and A. pasteiirianus were good producers, the 

 former yielding one isomer, the latter the other. 



Acetoin metabolism of bacteria in general has been 

 studied.^" 



Biosynthesis of acetoins has been reviewed.^" 



47a Galactosyl Lactose 



This trisaccharide was produced by Penicillhim chryso- 

 genum Thom on a lactose medium and assigned the 

 structure 0-/?-D-galactopyranosyl-(l -> 6)-0-/3-D-galacto- 

 pyranosyl-(l —> 4)-D-glucopyranose.^ 



Several papers have appeared on the mode of action of 



^ V. Musilek, V. Sevcik, M. Musilkova, J. Rokos and P. Prochazka, 

 Experientia 14 323 (1958). 



1" J. de Ley, J. Gen. Microbiol. 21 352-365 (1959). 



i^Yasuhiro Maeda, Okayama Igakkai Zasshi 71 8017 (1959). 

 (Chem. Abstr. 55 694i) 



1' H. Oberman, Postepy Biochemii 6 181-195 (1960). 



2 A Ballio and S. Russi, Tetrahedron 9 125 (1960). 



