663 



Addendum 



It has been reported that streptomycin inhibits de- 

 hydrogenases by influencing the apoenzyme/ The con- 

 clusion was made that further search for enzymatic 

 reactions susceptible to streptomycin should be aimed at 

 the study of its influence on intracellular synthetic proc- 

 esses, mainly the synthesis of nucleic acids and proteins. 



The mode of action of streptomycin in connection with 

 its binding by Mijcohacterimn avium has been studied.* 



The stereochemistry of neobiosamine B is as shown." 



HO— CH 



Neobiosamine B 



CHi— NH2 



Dextromycin is neomycin B and contains a small 

 amount of neomycin C.^" Framycetin also is identical 

 with neomycin B." 



59a Aminocidin (Crestomycin, Antibiotic 1600, Pharmiglucin, F. I. 

 5853) C03H45OJ4N, (Sulfate) [aW + 51° in water. Pro- 

 duced by Streptomyces crestomyceticus, n. sp.^- This 

 antibiotic seems to be similar to or identical with paromo- 

 mycin. 



" K. Michalska, Symposium on Antibiotics, Prague, 1959. 



^Tatsuji Kinoshita, Nagoija ]. Med. Sci. 21 323 (1958). 



" Kenneth L. Rinehart, Alexander D. Argoudelis, Townley P. Cul- 

 bertson, W. Scott Chilton and Klaus Streigler, J. Am. Chem. Soc. 82 

 2970 (1960). 



^° Sueo Tatsuoka, Akira Miyake and Hayao Nawa, /. Antibiotics 

 (Japan) llA 193 (1958). 



" Kenneth L. Rinehart, Jr., Alexander D. Argoudelis, William A. 

 Goss, Arthur Sohler and Carl P. Schaffner, /. Am. Chem. Soc. 82 

 3938 (1960). 



^- F. Arcamone, C. Bertazzoli, M. Ghione and T. Scotti, Giorn. 

 Microbiol. 7 251 (1959). 



