Pfizer Handbook of Microbial Metabolites 666 



Lipides of Corynebacterium ovis have been studied/" 

 as have the component fatty acids of Sporidesmium 

 bakeri Syd. Hpides.-" 



The oil of wheat stem rust uredospores was found to 

 contain a substantial quantity of an acid not previously 

 reported from natural sources, cis-9,10-epoxyoctadecanoic 

 acid, CisH;j40:t, colorless leaflets, m.p. 58.5-59.5°, cis- 

 epoxide peak in the infra-red at 845 cm.'.-' 



The chemistry of naturally occurring 1,2-epoxides, in- 

 cluding many microbial products, has been reviewed.''" 



Another new fatty acid, Ci^H.joO^, containing a cy- 

 clopropane ring has been reported (in a preliminary com- 

 munication) as occurring in Escherichia coli lipides." 



Bongkrekic acid, at a concentration of lO" molar, is a 

 potent inhibitor of oxidative phosphorylation as carried 

 out by mitochondrial enzymes in heart muscle tissue.-' 



The direct participation of protein-bound biotin in 

 fatty acid biosynthesis has been confirmed.-* 



Both 9- and 10-hydroxystearic acids can replace oleic 

 acid as growth factors for anaerobically grown yeast, 

 which requires unsaturated acid, and these substances 

 may be precursors of oleic acid in yeast. -"^ 



The role of vitamins in lipide metabolism has been re- 

 viewed.-'"' 



Hydroxypyruvic acid has been isolated as the 2,4-dini- 

 trophcnylhydrazone from Aspergillus nigcr. It may arise 

 from 3-phosphoglyceric acid.'-' 



i^A. Diara and J. Pudles, Bull. soc. chim. biol. 41 481 (1959). 



2" L. Hartman, J. C. Hawke, Isobel M. Morice and T. B. Shorland, 

 Biochem. J. 75 274 (1960). 



-' A. Tulloch, B. Craig and G. Ledingham, Can. J. Microbiol. 5 

 485 (1959). 



-i» A. D. Cross, Quart. Revs. II 317-336 (1960). 



" Simone Dauchy and Jean Asselineau, Compt. rend. 250 2635 

 (1960). 



-i W. Welling, J. A. Cohen and W. Berends, Biochem. Pharmacol. 

 3 122 (1960). 



-' S. J. Wakil and D. M. Gibson, Biochim. et Biophys. Acta. 41 122 

 (1960). 



'-'■'W. J. Lennarz and Konrad Bloch, ;. Biol. Chem. 235 PC 26 

 (1960). 



-"Bacon F. Chow, Avi. J. Clinical Nutrition 8 321 (1960). 



-'Francis J. Behal, Arch. Biochem. and Biophijs. 88 110 (1960). 



