673 Addendum 



209b Drosophilin D (cis-Undeca-3,9,10-trien-5,7-diynoic Acid), 

 C,,HsOo, colorless plates, m.p. 21-28°, U.V. 303.5, 290.5, 

 274.5, 259, 217 m^. 



H,C=C=CH— C=C— C^C— CH--CH— CH, -COOH 

 Drosophila subatrata 



219b Compound 3040 (Dimethyl trans-Undeca-2-en-4,6-diyn-l,ll- 

 dioate), C,.,Hi404, colorless crystals, m.p. 15-16°, U.V. 

 304, 286, 270, 255, 222.5, 215 m/x. 



CH3OOC— CH2— CH2— CH2— C=C— C^C— CH=CH— COOCH3 



Drosophila subatrata 



An Italian review on the chemical aspects of the basid- 

 iomycete antibiotics has been published. ''■^ 



7. Macrocyclic Lactones (Macrolides) 



A new tetraene antibiotic has been reported.^* 



233a Unamycin A, white needles, m.p. (dec.) 148-150°, [ajn^^ —92° 

 (c 1.0 in 80% methanol-water), U.V. 290, 304, 319 m/x 

 in methanol. 



An acidic tetraene. Negative FeCl^, Million, Fehling, 

 Tollens tests. Positive Molisch, KMn04 and Br^ tests. 

 Pink Schiff test. 



A second substance resembling toyocamycin was iso- 

 lated : 



1288a Unamycin B, white needles, m.p. 236-238° (dec), [ajn^^ -43° 

 (c 1.0 in acid methanol), N. E. 310. 



C 46.4, H 4.46, N 22.25. Gives essentially the same color 

 tests as unamycin A. 



The unamycins were produced by Streptomyces fungi- 

 cidicus. 



A heptaene which may be new has been reported." 



256a Grubilin green-yellow, amorphous. 



A non-toxic heptaene produced by Streptomyces BA-27, 



s^Marcella Magliola, Annali di Chimica 50 455-490 (1960). 



^* Masayuke Matsuoka and Hamao Umezawa, /. Antibiotics 

 (Japan) 13A 114 (1960). 



" J. Uri, I. Szilagyi and I. Bekesi, Symposium on Antibiotics, 

 Prague, 1959. 



