Pfizer Handbook of Microbial Metabolites 674 



and differing from amphotericin B, ascosin, airreofacin, 

 AYF, candicidin, candidin, candimycin, PA 150 and tri- 

 chomycin. 



Antimycoin has been separated into A and B compo- 

 nents.'^'' Mevalonic acid stimulated production of these 

 substances by Streptoinyces aureus. Of nine other 

 polyene producers tested, Streptoinyces viridoflavus pro- 

 duction of candidin and Streptoinyces strain 3832 produc- 

 tion of a pentaene (antibiotic S-8) of the eurocidin type 

 were stimulated by mevalonic acid addition. 



The mechanism of nystatin action on Candida albicans 

 has been studied.''' Respiration was accelerated and glu- 

 cose uptake diminished, apparently by alteration of cell 

 permeability. 



A dissertation has been published (not yet received) 

 entitled Beitrag zur Kentitnis des Candicidins D, G. 

 Demuth, Math.-Naturw. Fakultat der Univ. Gottingen, 

 1959. 



Some generalizations can be made now concerning the 

 structures of polyene macrolides.* Tetraenes and hep- 

 taenes generally seem to contain nitrogen, while pentaenes 

 and hexaenes do not. Moldicidin and PA- 153 are excep- 

 tions since they are nitrogen-containing pentaenes. All 

 tetraenes except PA-166 contain mycosamine. PA-166 

 contains an amino sugar (not a deoxy type) other than 

 mycosamine. Pentaenes are neutral, containing neither 

 amino sugars nor free carboxyl groups. 



Heptaenes have been found so far to contain four dif- 

 ferent nitrogen-containing moieties. Two of these are 

 the amino sugars previously mentioned. The other two 

 are the aromatic amines, p-aminoacetophenone and p- 

 aminophenylacetone, which are released by alkahne hy- 

 drolysis. " 



s« Robert Samuel Safferman, Dissertation Abstr. 20 4264 (1960). 



'"' J. W. Hai-man and J. G. Masterson, Irish J. Med. Sci. -$78 249 

 (1957). 



* Most of the information below on the polyene macrolides was 

 taken from a seminar given by Dr. Edward Borowsky, Visiting Pro- 

 fessor at the Institute for Microbiology at Rutgers University from 

 Gdansk, Poland, in August 1960 and will be published. 



