675 Addendum 



O O 



H,N— / \— C— CH3 H,N— / \— CH,— C— CH3 

 p-Aminoacetophenone p-Aminophenylacetone 



Amphotericin B and candidin are examples of heptaenes 

 containing mycosamine. Candicidin, trichomycin and 

 PA-150 contain p-aminoacetophenone. 



Hydrocandidin has yielded an oxidation fragment iden- 

 tified as: 



HOOC— CH-(CH,)u— CH— CO— CH3 



I I 



CH3 CH3 



Some studies on the biosynthesis of this heptaene show 

 no incorporation of labeled inevalonic acid, propionic acid 

 or methionine. It seems to be derived from acetate. 



The pentaene, moldicidin A, C4;{H220i9N was omitted. 



Moldicidin B is identical with pentamycin."" Can- 

 dicidin is identical with ascosin. The main component 

 of the PA-150 complex is identical with one compo- 

 nent of the candidin complex. Several substances listed 

 in the unclassified section are actually known to be 

 polyene macrolides. These include: 1072-aliomycin 

 (pentaene), 1067-akitamycin (tetraene), 1095-antibiotic 

 from Streptomyces fimgicidicus (tetraene), 1096-antibi- 

 otic from S. griseus (heptaene), 1097-antibiotic 26/1 

 (heptaene), 1294-substance 1404 (hexaene). 



A new heptaene, perimycin (aminomycin), probably 

 C47H-.-,Oi4N2 and incorporating a p-aminophenyl group, 

 has been reported. ^"^ Another heptaene, antibiotic 2814H, 

 is produced together with a pentaene, antibiotic 2814P, 

 netropsin and aureothin by Streptomyces lA 2814 resem- 

 bling S. netropsis.-'-' Analytical and optical data were re- 

 ported on each. 



•"" Hiroshi Ogawa, Teiichiro Ito, Shigeharu Inoue and Motohiro 

 Nishio, /. Antibiotics (Japan) 13A 353 (1960). 



■''''Edward Borowsky et al.. Abstracts 1960 Conference on Anti- 

 microbial Agents, Washington, D. C, October 26-28, 1960. 



'''■' Heinz Thrum and I-dschang Dcho, N atiirwissenschaften 20 474 

 (1960). 



