Pfizer Handbook of Microbial Metabolites 676 



The complete structures of the tetraenes, lagosin and 

 filipin have been reported to be : ^° 



CsHu— CH— OH OH OH R=OH=lagosin, C35H58O12 



I I I R=H=filipin, CssHssOu 



O— CO— CH (CH— CH2)5— CH— CH— R 



I 1 



CH3— CH— CH— (CH=CH)4— CH=C CH— OH 



I I 



OH CH3 



Humidin (Cj2H2o04)n, colorless plates, m.p. 145-146° 

 (dec), [aln'* -6° (c 1.0 in ethanol), mol. wt. 550 ± 50, 

 823 ± 10, is an antifungal antibiotic isolated from the 

 myceUum of Streptomyces humidus, which also produces 

 dihydrostreptomycin.^^ It was not clear from the abstract 

 whether or not this substance was of the polyene mac- 

 rolide type. 



Some aspects of the mode of action of polyene anti- 

 fungal antibiotics have been reviewed."^ 



A nitrogen-containing antifungal polyene antibiotic, 

 capacidin, produced by a streptomycete has been iso- 

 lated.®^- ®* The substance is levorotatory, has reducing 

 properties, is a primary or secondary alcohol and shows 

 ultraviolet absorption peaks at 318, 332, 350 m^^. 



A general review of the polyene antifungal antibiotics 

 has been published. '^^ 



Two new antibiotics have been reported, one of them, 

 at least, apparently a macrolide.*^® 



^^M. L. Dhar, V. Thaller and M. C. Whiting, Proc. Chem. Soc, 

 310 (1960). 



**i Koichi Nakazawa, Motoo Shibata, Hiroichi Yamamoto, Toshihiko 

 Kanzaki, Eiji Higashide, Akira Miyake and Satoshi Horii, Nippon 

 Nogei Kagaku Kaishi 32 713 (1958). (Chem. Abstr. 54 22843g) 



^^ E. Drouhet, L. Hirth and G. Lebeurier, Annals N. Y. Acad. Sci. 

 89 134-155 (1960). 



83 Rachel Brown and Elizabeth Hazen, N. Y. State Dept. Health, 

 Ann. Rept. Div. Labs, and Research 50-52 (1959). (Chem Abstr. 

 54 22824h) 



^Idem., Antibiotics and Chemotherapy 10 702 (1960). 



«5L. C. Vining, Hindu Antibiotics Bulletin 3 37-55 (1960). 



8" E. Gaumann, R. Hiitter, W. Keller-Schierlein, L. Neipp, V. Prelog 

 and H. Zahner, Helv. Chim. Acta 43 601 (1960). 



