679 Addendum 



30le Sarkomycin S^, CnH,sO,;So, m.p. 161°, [a],," +145°. 

 COOH COOH 



/ y-CHj— S— S— CH 



\ / 



o o 



30if Sarkomycin S;;, m.p. 148°. 



C 50.39, H 5.31, S 15.75. 



9. Terpenoids and Steroids 



A new trichothecin-like antibiotic has been isolated 

 from a basidiomycete." 



The oil of wheat stem rust uredospores contains A'- 

 ergostenol (fungisterol).'*-^ 



Another steroidal metabolite of Poria cocos has been 

 isolated and characterized. It is:" 



354a Pachymic Acid ( 3/3-0-Acetylpolyporenic Acid B), CasH-.^O-,, col- 

 ' orless crystals, m.p. 296-299°, [a]D"' 17.7° (c 0.566 in 

 pyridine ) . 



HOOC 



CH3COO 



Cholesterol biosynthesis is inhibited by farnesoic acid 

 and its analogues.'^ 



The conversion of mevalonate to a mixture of farnesol 

 and nerolidol (probably as their pyrophosphates) by a 



" Ervln Glaz, Eszter Scheiber, J. Gyimesi, I. Horvath, Katalin 

 Steczek, A. Szentirmai and G. Bohus, Nature 184 Suppl. No. 12, 908 

 (1959). 



'^ Shoji Shibata, Shinsaku Natorl, Ko Fujita, Isao Kitagawa and 

 Kazue Watanabe, Chem. & Pharm. Bull. (Tokyo) 6 608 (1958). 



'^G. Popjak, Rita H. Cornforth and K. Clifford, Lancet, 1270 

 (1960). 



