685 



Addendum 



ture of thelephoric acid (entry 493).^^ "^ The second 

 publication cited reported the synthesis of thelephoric 

 acid and seems to establish the structure definitely as: 



O 



HO 



HO 



OH 



OH 



Oosporein (chaetomidin) (entry 487) is reported to be 

 identical with isooosporein (entry 488).^"" 



A reinvestigation of quinones produced by Phoma ter- 

 restris Hansen identified cynodontin and a small amount 

 of another anthraquinone, but found no phomazarin (en- 

 try 556).'"! 



13. Tetracycline, Analogues and Related Substances 



The aglycone, aklavinone, of the antibiotic aklavin has 

 been found to differ from rutilantinone ( e-pyrromyci- 

 none) only by lacking one hydroxyl group/"^ 



OH OH 



Aklavinone C22H20O8 



OH O 



COOCH3 



Rutilantinone C22H20O9 



A biogenesis was postulated in the following sense: 

 0000 



^^ K. Aghoramurthy, K. G. Sarma and T. R. Seshadri, Tetrahedron 

 Letters No. 16 4 (1960). 



9»J. Gripenberg, Tetrahedron 10 135 (1960). 



i°o J. Smith and R. H. Thomson, ibid. 10 148 (1960). 



"ID. E. Wright and K. Schofield, Nature 188 233 (1960). 



102 J. J. Gordon, L. M. Jackman, W. D. QUis and I. O. Sutherland, 

 Tetrahedron Letters No. 8 28 (1960). 



