687 Addendum 



14. Aromatic Compounds Not Classified Elsewhere 



The cooccurrence of anisaldehyde and junipal in 

 Dacdalca jutupcrina cultures has inspired the suggestion 

 that both substances are derived from a common acety- 

 lenic precursor.'"' "- An eai'lier report that Poliiporiis 

 beuzoiuus produces considerable quantities of anisalde- 

 hyde was not mentioned in our entry on that substance."^ 



15. Amines 



Although the ordinary source of the amine, carnitine, 

 is mammalian muscle, a publication was overlooked in 

 which it was isolated from the mold Neurospora crassa 

 grown on a chemically defined medium."* 



653a L-Carnitine, C7H]-0;iN, extremely hygroscopic crystals, m.p. 

 196-198°, [a],,'-" -23.5° (c 0.5 in water). 



® 



(CH3)3N— CH2— CH— CH2— COO ^ 



OH 



This amine would not replace choline in choline-less 

 neurospora mutants. It was not found in E. coli. The 

 role of carnitine in lipide metabolism has been re- 

 viewed."^' ^^^ 



An amine related to muscarine has been isolated and 

 characterized by synthesis.""' "* It is: 



658a ( + )-Muscaridine, C,,H..0._.NC1 (Chloroaurate), C.,H..AuCl40.N, 

 m.p. 129-131°, UW -f20.5° ±0.5° (c 8.3 in water). 



"1 J. H. Birkinshaw and P. Chaplen, Biochem. J. 60 255 (1955). 



11- K. E. Schulte and N. Jantos, Arch. Pharm. 292 536 (1959). 



^^^ J. H. Birkinshaw, E. N. Morgan and W. P. K. Flndlay, Biochem. 

 J. 50 509 (1952). 



"*G. Fraenkel, Biol. Bull. 104 359 (1953). 



"' G. Fraenkel and S. Freedman, Vitamins and Hormo7ies 15 74- 

 115 (1957). 



""E. P. Adams, P. E. Ballance and A. E. Bender, Nature 185 612 

 (1960). 



"■ F. Kogl, C. A. Salemink and P. L. Schuller, Rec. trav. chim. 79 

 278 (1960). 



"'^C. A. Salemink and P. L. SchuUer, ibid. 79 485 (1960). 



