Pfizer Handbook of Microbial Metabolites 688 



© CI e 



(CHalsN CH,— CHo— CHo— CH— CH— CH3 



I I 



OH OH 



Amanita muscaria 



A survey of 32 fungi and nine bacteria indicated that 

 the production of choline sulfate is limited to the higher 

 fungi. ^^^ All bacteria were negative as were phycomy- 

 cetes. Of the ascomycetes, spharioles produced it, but 

 endomycetales did not. Basidiomycetes and all fungi 

 imperfecti examined (except Torula utilis) were pro- 

 ducers. 



List has continued his investigations of the basic con- 

 stituents of higher fungi. From Polyporus sulfureus 

 were isolated the following non-volatile substances: ade- 

 nine, hypoxanthine, arginine, histidine, lysine, choHne, 

 histidine betaine, phenylethylamine, imidazolyl acetate, 

 homarine, trigonelHne, y-butyrobetaine and an uncharac- 

 terized hydrochloride, C9Hi6N2-2HCl.^-° 



The mushroom Coprinus atramentarius was studied. ^^^ 

 A prior report that it produced tetraethylthiuram disul- 

 fide could not be confirmed. Found, however, were iso- 

 amylamine, phenylethylamine, adenine, hypoxanthine, 

 urocanic acid, imidazolyacetic acid, imidazolylpropionic 

 acid, imidazolylethanol, histidine, arginine, choline, ly- 

 sine, guanidine, ergothioneine, hercynine, glycine, be- 

 taine, tyramine, putrescine, cadaverine, S-aminovaleric 

 acid, a-guanidinobutyric acid, two unidentified bases, 

 glycine, threonine, glutamic acid, aspartic acid, alanine, 

 proline, leucine, valine, isoleucine, citrulline, tyrosine 

 and ornithine. 



A dissertation has been published on basic constituents 

 and amino acids of the basidiomycete, Inocybe patoul- 

 lardii Bres.^-- 



Found were methylamine, dimethylamine, ethylamine, 

 n-propylamine, isoamylamine, /?-phenylethylamine, cho- 

 line, cadaverine, putrescine, hypoxanthine, alanine, pro- 

 lix T. Harada and B. Spender, /. Gen. Microbiol. 22 520 (1960). 

 120 p. List and H. Menssen, Arch. Pharm. 292 260-271 (1959). 

 ^21 p. H. List and H. Reith, Arzneimittel-Forsch. 10 34-40 (1960). 

 ^2- H. Miiller, Dissertation, Naturw. Fakultat Univ. Wiirzburg, 

 1959. 



